Epigenetik - Versionsgeschichte

Fmrauch: etwas mehr Kriti

2020-08-13T08:25:38Z

etwas mehr Kriti

← Nächstältere Version		Version vom 13. August 2020, 08:25 Uhr
Zeile 1:		Zeile 1:
	Die '''Epigenetik''' (von {{ELSalt\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref>		Die '''Epigenetik''' (von {{ELSalt\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref>

	Manche ~~Theorien~~ der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen. Daher werden viele neue [[Hypothese]]n in diesem Zusammenhang als „unwissenschaftlich“ kritisiert. Allerdings gibt es auch Beobachtungen, die sich mit den heutigen Erkenntnissen der Genetik nicht erklären lassen.<ref>https://www.faz.net/aktuell/wissen/leben-gene/immunsystem-von-tiefseefischen-bis-dass-der-tod-sie-scheidet-16889042.html</ref>		Manche [[Theorie]]n der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] (1744-1829) zurückführen und tauchen zum Beispiel auch in den Büchern von [[Mathilde Ludendorff]] auf. Daher werden viele neue [[Hypothese]]n in diesem Zusammenhang als „unwissenschaftlich“ kritisiert. Allerdings gibt es auch Beobachtungen, die sich mit den heutigen Erkenntnissen der Genetik nicht erklären lassen.<ref>https://www.faz.net/aktuell/wissen/leben-gene/immunsystem-von-tiefseefischen-bis-dass-der-tod-sie-scheidet-16889042.html</ref>

	== Bibliographie ==		== Bibliographie ==

Fmrauch: eine deutsche Quelle

2020-08-13T08:23:25Z

eine deutsche Quelle

← Nächstältere Version		Version vom 13. August 2020, 08:23 Uhr
Zeile 1:		Zeile 1:
	Die '''Epigenetik''' (von {{ELSalt\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.		Die '''Epigenetik''' (von {{ELSalt\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref>

			Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen. Daher werden viele neue [[Hypothese]]n in diesem Zusammenhang als „unwissenschaftlich“ kritisiert. Allerdings gibt es auch Beobachtungen, die sich mit den heutigen Erkenntnissen der Genetik nicht erklären lassen.<ref>https://www.faz.net/aktuell/wissen/leben-gene/immunsystem-von-tiefseefischen-bis-dass-der-tod-sie-scheidet-16889042.html</ref>

	== Bibliographie ==		== Bibliographie ==

Fmrauch am 13. August 2020 um 07:58 Uhr

2020-08-13T07:58:06Z

← Nächstältere Version		Version vom 13. August 2020, 07:58 Uhr
Zeile 1:		Zeile 1:
	~~{{Inuse}}~~		Die '''Epigenetik''' (von {{ELSalt\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.
	Die '''Epigenetik''' (~~[[Altgriechische Sprache\|altgr.]]~~ {{~~lang\|grc~~\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.

	== Bibliographie ==		== Bibliographie ==

Fmrauch am 13. August 2020 um 07:57 Uhr

2020-08-13T07:57:15Z

← Nächstältere Version		Version vom 13. August 2020, 07:57 Uhr
Zeile 1:		Zeile 1:
	{{Inuse}}		{{Inuse}}
	Die '''Epigenetik''' ([[Altgriechische Sprache\|altgr.]] {{lang\|grc\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die [[~~Genexpression\|Aktivität eines Gens~~]] und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] ~~zeitweilig~~ festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.		Die '''Epigenetik''' ([[Altgriechische Sprache\|altgr.]] {{lang\|grc\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die Aktivitäten eines [[Gen]]s und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.

	== Bibliographie ==		== Bibliographie ==

Fmrauch: wiss. Tradition

2020-08-13T07:56:21Z

wiss. Tradition

← Nächstältere Version		Version vom 13. August 2020, 07:56 Uhr
Zeile 1:		Zeile 1:
	{{Inuse}}		{{Inuse}}
	Die '''Epigenetik''' ([[Altgriechische Sprache\|altgr.]] {{lang\|grc\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die [[Genexpression\|Aktivität eines Gens]] und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] zeitweilig festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref>		Die '''Epigenetik''' ([[Altgriechische Sprache\|altgr.]] {{lang\|grc\|ἐπί}} ''epi'' ‚dazu‘, ‚außerdem‘ und ''[[Genetik]]'') ist das Fachgebiet der [[Biologie]], das sich mit der Frage befasst, welche Faktoren die [[Genexpression\|Aktivität eines Gens]] und damit die Entwicklung der [[Zelle (Biologie)\|Zelle]] zeitweilig festlegen. Sie untersucht die Änderungen der Genfunktion, die nicht auf Veränderungen der Sequenz der [[Desoxyribonukleinsäure]], etwa durch [[Mutation]] oder Rekombination, beruhen und dennoch an Tochterzellen weitergegeben werden.<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref> Manche Theorien der Epigenetik lassen sich auf den französischen Botaniker und Zoologe [[Jean-Baptiste Lamarck]] zurückführen.

	== Bibliographie ==		== Bibliographie ==

Fmrauch: Kat.

2020-08-13T07:53:51Z

Kat.

← Nächstältere Version		Version vom 13. August 2020, 07:53 Uhr
Zeile 5:		Zeile 5:
	<references />		<references />
	{{PPA-Kupfer}}		{{PPA-Kupfer}}

			[[Kategorie:Genetik]]
			[[Kategorie:Evolution]]

Fmrauch: Text dazu

2020-08-13T07:10:01Z

Text dazu

Änderungen zeigen

Ossip Groth am 9. März 2010 um 18:08 Uhr

2010-03-09T18:08:27Z

← Nächstältere Version		Version vom 9. März 2010, 18:08 Uhr
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	\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''
	\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref>		\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID10986038">Mechanisms of genomic imprinting. Am J Hum Genet 67(4):777-87 (2000) PMID 10986038 </ref><ref name="PMID9399913">Genomic imprinting: a chromatin connection. Am J Hum Genet 61(6):1213-9 (1997) PMID 9399913 </ref><ref name="PMID10079240">Genomic imprinting: implications for human disease. Am J Pathol 154(3):635-47 (1999) PMID 10079240 </ref><ref name="PMID8129028">Genomic imprinting: mechanism and role in human pathology. Am J Pathol 144(3):431-43 (1994) PMID 8129028 </ref><ref name="PMID17968922">Epigenetics in inflammatory rheumatic diseases. Arthritis Rheum 56(11):3523-31 (2007) PMID 17968922 </ref><ref name="PMID10397708">Chromatin remodeling and leukemia: new therapeutic paradigms. Blood 94(2):417-28 (1999) PMID 10397708 </ref><ref name="PMID10361102">DNA methylation. Blood 93(12):4059-70 (1999) PMID 10361102 </ref><ref name="PMID19429783">The function of non-coding RNAs in genomic imprinting. Development 136(11):1771-83 (2009) PMID 19429783 </ref><ref name="PMID16672331">Chromatin and epigenetics in development: blending cellular memory with cell fate plasticity. Development 133(11):2089-94 (2006) PMID 16672331 </ref><ref name="PMID17998808">Environmental epigenomics, imprinting and disease susceptibility. Epigenetics 1(1):1-6 (2006) PMID 17998808 </ref><ref name="PMID16840508">Colorectal cancer: a model for epigenetic tumorigenesis. Gut 56(1):140-8 (2007) PMID 16840508 </ref><ref name="PMID17613545">Different epigenetic layers engage in complex crosstalk to define the epigenetic state of mammalian rRNA genes. Hum Mol Genet 16 Spec No 1():R21-7 (2007) PMID 17613545 </ref><ref name="PMID16987876">How lifetimes shape epigenotype within and across generations. Hum Mol Genet 15 Spec No 2():R131-7 (2006) PMID 16987876 </ref><ref name="PMID16651376">The emerging science of epigenomics. Hum Mol Genet 15 Spec No 1():R95-101 (2006) PMID 16651376 </ref><ref name="PMID15809273">Epigenetic reprogramming in mammals. Hum Mol Genet 14 Spec No 1():R47-58 (2005) PMID 15809273 </ref><ref name="PMID15809272">Epigenetic control in the immune response. Hum Mol Genet 14 Spec No 1():R41-6 (2005) PMID 15809272 </ref><ref name="PMID15809270">From genome to epigenome. Hum Mol Genet 14 Spec No 1():R3-R10 (2005) PMID 15809270 </ref><ref name="PMID15809262">Phenotypic differences in genetically identical organisms: the epigenetic perspective. Hum Mol Genet 14 Spec No 1():R11-8 (2005) PMID 15809262 </ref><ref name="PMID15809261">Remote control of gene transcription. Hum Mol Genet 14 Spec No 1():R101-11 (2005) PMID 15809261 </ref><ref name="PMID9735381">A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Hum Mol Genet 7(10):1599-609 (1998) PMID 9735381 </ref><ref name="PMID10683367">Epigenetic gene silencing in cancer. J Clin Invest 105(4):401-7 (2000) PMID 10683367 </ref><ref name="PMID2231652">Chromosome imbalance, normal phenotype, and imprinting. J Med Genet 27(9):582-7 (1990) PMID 2231652 </ref><ref name="PMID19005036">Epigenetics in the nervous system. J Neurosci 28(46):11753-9 (2008) PMID 19005036 </ref><ref name="PMID16280577">Epigenetic mechanisms and gene networks in the nervous system. J Neurosci 25(45):10379-89 (2005) PMID 16280577 </ref><ref name="PMID17121465">Genomic imprinting in mammals: emerging themes and established theories. PLoS Genet 2(11):e147 (2006) PMID 17121465 </ref><ref name="PMID17675334">The dynamic epigenome and its implications in toxicology. Toxicol Sci 100(1):7-23 (2007) PMID 17675334 </ref>
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	== Bibliographie ==		== Bibliographie ==
	<references />		<references />
			{{LinkWP_Miniartikel\|Txt=Epigenetik\|Link=Epigenetik}}


	{{LinkWP_Miniartikel}}

Ossip Groth am 27. Januar 2010 um 19:57 Uhr

2010-01-27T19:57:33Z

← Nächstältere Version		Version vom 27. Januar 2010, 19:57 Uhr
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	[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]		[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]
	{\| class="wikitable" \|		{\| class="wikitable" \|
	\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''
	\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref>		\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref>
	\|-		\|-
	\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''

Ossip Groth am 27. Januar 2010 um 19:44 Uhr

2010-01-27T19:44:25Z

← Nächstältere Version		Version vom 27. Januar 2010, 19:44 Uhr
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	[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]		[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]
	{\| class="wikitable" \|		{\| class="wikitable" \|
	\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''
	\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref>		\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref>
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	\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''

← Nächstältere Version		Version vom 27. Januar 2010, 19:57 Uhr
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	[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]		[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]
	{\| class="wikitable" \|		{\| class="wikitable" \|
	\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''
	\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref>		\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref><ref name="PMID11051542">Noncoding RNA genes in dosage compensation and imprinting. Cell 103(1):9-12 (2000) PMID 11051542 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref>
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	\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''

← Nächstältere Version		Version vom 27. Januar 2010, 19:44 Uhr
Zeile 1:		Zeile 1:


	[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]		[[Datei:pptpdtjpg1.png\|miniatur\|Entstehender Artikel]]
	{\| class="wikitable" \|		{\| class="wikitable" \|
	\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Freie Übersichtsartikel'''
	\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref>		\| align="left" width="800" \|<ref name="PMID16515724">Epigenetic regulation: DNA confers identity but is not enough to maintain it. Genome Biol 7(1):302 (2006) PMID 16515724 </ref><ref name="PMID12620100">The epigenetics of the cell. Genome Biol 4(3):309 (2003) PMID 12620100 </ref><ref name="PMID17320511">Genetic and epigenetic regulators of pluripotency. Cell 128(4):747-62 (2007) PMID 17320511 </ref><ref name="PMID17320506">The epigenomics of cancer. Cell 128(4):683-92 (2007) PMID 17320506 </ref><ref name="PMID17320505">The mammalian epigenome. Cell 128(4):669-81 (2007) PMID 17320505 </ref><ref name="PMID17320504">Timescales of genetic and epigenetic inheritance. Cell 128(4):655-68 (2007) PMID 17320504 </ref><ref name="PMID9590162">Imprinting and the initiation of gene silencing in the germ line. Cell 93(3):309-12 (1998) PMID 9590162 </ref><ref name="PMID9590160">The mystique of epigenetics. Cell 93(3):301-3 (1998) PMID 9590160 </ref><ref name="PMID3049238">Genomic imprinting. Genes Dev 2(8):921-5 (1988) PMID 3049238 </ref><ref name="PMID9750189">Imprinting mechanisms. Genome Res 8(9):881-900 (1998) PMID 9750189 </ref><ref name="PMID11030613">Pausing for thought on the boundaries of imprinting. Cell 102(6):705-8 (2000) PMID 11030613 </ref><ref name="PMID15324678">Genomic imprinting. Curr Biol 14(16):R646-9 (2004) PMID 15324678 </ref><ref name="PMID10873799">Transcriptional control: imprinting insulation. Curr Biol 10(12):R463-5 (2000) PMID 10873799 </ref><ref name="PMID10744967">Transcriptional control: The benefits of selective insulation. Curr Biol 10(6):R241-4 (2000) PMID 10744967 </ref>
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	\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''		\| bgcolor="#dfdfdf" \| '''Wichtige Übersichtsartikel'''