https://ddn.pluspedia.org/w/index.php?action=history&feed=atom&title=SM16
SM16 - Versionsgeschichte
2026-04-25T21:44:37Z
Versionsgeschichte dieser Seite in PlusPedia
MediaWiki 1.43.3
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=556335&oldid=prev
Fmrauch: /* Bitte beachten */
2017-07-21T21:52:06Z
<p><span class="autocomment">Bitte beachten</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 21. Juli 2017, 21:52 Uhr</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Bitte beachten Sie den [[Warnhinweis Gesundheitsthemen]].</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Gesundheitshinweis}}</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td></tr>
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Fmrauch
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=556272&oldid=prev
Fmrauch: Kategorie usw.
2017-07-21T20:18:25Z
<p>Kategorie usw.</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 21. Juli 2017, 20:18 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Adoptive T-Zellen-Therapie im xenogenen Thymom Huhn auf Maus ===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Adoptive T-Zellen-Therapie im xenogenen Thymom Huhn auf Maus ===</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Es werden in der SM16 unterstützten Gruppe kleinere Tumoren gesehen. Die verschiedenen möglichen Effekte (Regulatorische T-Zellen, M2 Makrophagen) werden diskutiert.<ref name="PMID18559619">Wallace A. et al., Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14(12):3966-74 (2008) PMID 18559619 </ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Es werden in der SM16 unterstützten Gruppe kleinere Tumoren gesehen. Die verschiedenen möglichen Effekte (Regulatorische T-Zellen, M2 Makrophagen) werden diskutiert.<ref name="PMID18559619">Wallace A. et al., Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14(12):3966-74 (2008) PMID 18559619 </ref></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Humanmedizin ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Ausblick ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Ausblick ==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><references /></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><references /></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Init</del>-<del style="font-weight: bold; text-decoration: none;">Quelle ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{PPA</ins>-<ins style="font-weight: bold; text-decoration: none;">Mars}}</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Entnommen aus der:</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">* [http://de.wikipedia.org/wiki/SM16 Wikipedia] </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://de.wikipedia.org/wiki/Wikipedia:L%C3%B6schkandidaten/23._November_2009#SM16_.28Gel.C3.B6scht.29 Löschdiskussion bei Wikipedia]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://de.wikipedia.org/wiki/Wikipedia:L%C3%B6schkandidaten/23._November_2009#SM16_.28Gel.C3.B6scht.29 Löschdiskussion bei Wikipedia]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Erster Autor: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], <del style="font-weight: bold; text-decoration: none;">Alle Autoren</del>: <del style="font-weight: bold; text-decoration: none;">[http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], </del>[http://de.wikipedia.org/wiki/Benutzer:Lantus Lantus]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Erster Autor: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], <ins style="font-weight: bold; text-decoration: none;">weiterer Autor</ins>: [http://de.wikipedia.org/wiki/Benutzer:Lantus Lantus]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Kategorie:WikiPedia Deleted]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Kategorie:Medizin]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Kategorie:Medikament]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Kategorie:Medikament]]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{PPA-Eisen}}</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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Fmrauch
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=410029&oldid=prev
TX500 am 7. Dezember 2013 um 09:11 Uhr
2013-12-07T09:11:10Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 7. Dezember 2013, 09:11 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Init-Quelle ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Init-Quelle ==</div></td></tr>
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TX500
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=410028&oldid=prev
TX500: Umgruppiert, Warnhinweis
2013-12-07T09:09:59Z
<p>Umgruppiert, Warnhinweis</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 7. Dezember 2013, 09:09 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Das Medikament wird zur klinischen Entwicklung geführt.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Das Medikament wird zur klinischen Entwicklung geführt.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Einzelnachweise ==</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>{{<del style="font-weight: bold; text-decoration: none;">LinkWP_Miniartikel|Txt=SM16|Link=DELETED</del>}}</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Kategorie:Medizin]]</ins></div></td></tr>
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TX500
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=44278&oldid=prev
Ossip Groth: /* Init-Quelle */
2010-04-16T16:31:59Z
<p><span class="autocomment">Init-Quelle</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 16. April 2010, 16:31 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Kategorie:WikiPedia Deleted]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Kategorie:WikiPedia Deleted]]</div></td></tr>
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Ossip Groth
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=7963&oldid=prev
Administrator Glenn v. B.: typo
2009-12-13T01:30:17Z
<p>typo</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 13. Dezember 2009, 01:30 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Tiermodelle ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Tiermodelle ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>=== Ballondilatationsbedingte Arteriosklerose der A.carotis ===</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>=== Ballondilatationsbedingte Arteriosklerose der A. carotis ===</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Inhibiert werden Kollagenablagerung, Myofibroblasten (Adventitia), Neointimabreite. Sowohl TGFbeta als auch Aktivin sind als primär pathogene Mediatoren zu diskutieren.<ref name="PMID18202322">Fu K. et al., SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol 28(4):665-71 (2008) PMID 18202322 </ref></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Inhibiert werden Kollagenablagerung, Myofibroblasten (Adventitia), Neointimabreite. Sowohl TGFbeta als auch Aktivin sind als primär pathogene Mediatoren zu diskutieren.<ref name="PMID18202322">Fu K. et al., SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol 28(4):665-71 (2008) PMID 18202322 </ref></div></td></tr>
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Administrator Glenn v. B.
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=7962&oldid=prev
Administrator Glenn v. B.: typo
2009-12-13T01:28:30Z
<p>typo</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 13. Dezember 2009, 01:28 Uhr</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Immunevasion Mesotheliom ===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Immunevasion Mesotheliom ===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Durch systemische und lokale Inhibition der (bei Mesotheliomen erheblichen Synthese) TGF beta Wirkung werden dessen immunregulatorische Effekte so modifiziert, <del style="font-weight: bold; text-decoration: none;">daß </del>eine effizientere endogene Tumorimmunität resultiert. Durch dauerhafte Gabe von SM16 gelingt eine Verlangsamung des Tumorwachstums; ebenfalls wird erfolgreich ein adjuvantes Konzept nach Debulking dargestellt.<ref name="PMID17332368">Suzuki E. et al., A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res 67(5):2351-9 (2007) PMID 17332368 </ref></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Durch systemische und lokale Inhibition der (bei Mesotheliomen erheblichen Synthese) TGF beta Wirkung werden dessen immunregulatorische Effekte so modifiziert, <ins style="font-weight: bold; text-decoration: none;">das </ins>eine effizientere endogene Tumorimmunität resultiert. Durch dauerhafte Gabe von SM16 gelingt eine Verlangsamung des Tumorwachstums; ebenfalls wird erfolgreich ein adjuvantes Konzept nach Debulking dargestellt.<ref name="PMID17332368">Suzuki E. et al., A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res 67(5):2351-9 (2007) PMID 17332368 </ref></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Adoptive T-Zellen-Therapie im xenogenen Thymom Huhn auf Maus ===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>=== Tumorbiologie: Adoptive T-Zellen-Therapie im xenogenen Thymom Huhn auf Maus ===</div></td></tr>
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Administrator Glenn v. B.
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=7961&oldid=prev
Administrator Glenn v. B.: typo
2009-12-13T01:22:14Z
<p>typo</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Version vom 13. Dezember 2009, 01:22 Uhr</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>SM16 ist ein experimentelles [[Fibrose|antifibrotisches]] Medikament.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''</ins>SM16<ins style="font-weight: bold; text-decoration: none;">''' </ins>ist ein experimentelles [[Fibrose|antifibrotisches]] Medikament.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Entdeckung ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Entdeckung ==</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://de.wikipedia.org/wiki/Wikipedia:L%C3%B6schkandidaten/23._November_2009#SM16_.28Gel.C3.B6scht.29 Löschdiskussion bei Wikipedia]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://de.wikipedia.org/wiki/Wikipedia:L%C3%B6schkandidaten/23._November_2009#SM16_.28Gel.C3.B6scht.29 Löschdiskussion bei Wikipedia]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Erster Autor: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Erster Autor: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], Alle Autoren: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], [http://de.wikipedia.org/wiki/Benutzer:Lantus Lantus]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>, Alle Autoren: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], [http://de.wikipedia.org/wiki/Benutzer:Lantus Lantus]</div></td><td colspan="2" class="diff-side-added"></td></tr>
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Administrator Glenn v. B.
https://ddn.pluspedia.org/w/index.php?title=SM16&diff=7857&oldid=prev
217.227.171.120: Init
2009-12-12T23:35:00Z
<p>Init</p>
<p><b>Neue Seite</b></p><div>SM16 ist ein experimentelles [[Fibrose|antifibrotisches]] Medikament.<br />
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== Entdeckung ==<br />
SM16 wurde als kompetitiver Inhibitor an der ATP Bindungstellte der ALK5 Rezeptorkinase entwickelt. Strukturformel in.<ref name="PMID18202322">Fu K. et al., SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol 28(4):665-71 (2008) PMID 18202322 </ref><br />
Es wird von [[Biogen IDEC]], Cambridge, Mass., entwickelt.<br />
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== Wirkmechanismus ==<br />
SM16 hemmt die Signaltransduktion über ALK5 (TGF beta1) und ALK4 (Aktivin A), in hoher Konzentration p38MAPK und Raf.<br />
IC50 für ALK5 etwa 200 nM.<br />
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== Tiermodelle ==<br />
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=== Ballondilatationsbedingte Arteriosklerose der A.carotis ===<br />
Inhibiert werden Kollagenablagerung, Myofibroblasten (Adventitia), Neointimabreite. Sowohl TGFbeta als auch Aktivin sind als primär pathogene Mediatoren zu diskutieren.<ref name="PMID18202322">Fu K. et al., SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol 28(4):665-71 (2008) PMID 18202322 </ref><br />
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=== Tumorbiologie: Immunevasion Mesotheliom ===<br />
Durch systemische und lokale Inhibition der (bei Mesotheliomen erheblichen Synthese) TGF beta Wirkung werden dessen immunregulatorische Effekte so modifiziert, daß eine effizientere endogene Tumorimmunität resultiert. Durch dauerhafte Gabe von SM16 gelingt eine Verlangsamung des Tumorwachstums; ebenfalls wird erfolgreich ein adjuvantes Konzept nach Debulking dargestellt.<ref name="PMID17332368">Suzuki E. et al., A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res 67(5):2351-9 (2007) PMID 17332368 </ref><br />
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=== Tumorbiologie: Adoptive T-Zellen-Therapie im xenogenen Thymom Huhn auf Maus ===<br />
Es werden in der SM16 unterstützten Gruppe kleinere Tumoren gesehen. Die verschiedenen möglichen Effekte (Regulatorische T-Zellen, M2 Makrophagen) werden diskutiert.<ref name="PMID18559619">Wallace A. et al., Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers. Clin Cancer Res 14(12):3966-74 (2008) PMID 18559619 </ref><br />
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== Humanmedizin ==<br />
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== Ausblick ==<br />
Das Medikament wird zur klinischen Entwicklung geführt.<br />
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== Einzelnachweise ==<br />
<references /><br />
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== Init-Quelle ==<br />
Entnommen aus der:<br />
* [http://de.wikipedia.org/wiki/SM16 Wikipedia] <br />
* [http://de.wikipedia.org/wiki/Wikipedia:L%C3%B6schkandidaten/23._November_2009#SM16_.28Gel.C3.B6scht.29 Löschdiskussion bei Wikipedia]<br />
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Erster Autor: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth]<br />
, Alle Autoren: [http://de.wikipedia.org/wiki/Benutzer:Ossip groth Ossip groth], [http://de.wikipedia.org/wiki/Benutzer:Lantus Lantus]<br />
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[[Kategorie:WikiPedia Deleted]]</div>
217.227.171.120